Autologous IL-7Ra-expressing Tris-CAR T cells

{
  "id": "MLC-T-ONC-011669",
  "term": "Autologous IL-7Ra-expressing Tris-CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified and lentivirally transduced to express a dual-target chimeric antigen receptor (CAR) and a truncated form of the cytokine receptor interleukin-7 (IL-7) receptor alpha (IL-7Ra), with potential immunostimulating and antineoplastic activities. Upon administration, autologous IL-7Ra-expressing Tris-CAR T cells target and bind to tumor cells expressing the targets, thereby inducing selective toxicity in these tumor cells. In addition, as IL-7/IL-7Ra-mediated signaling promotes the proliferation and survival of T cells, these tumor re-directed T cells may show enhanced expansion, survival and cytotoxicity.",
  "synonyms": [
    "autologous Tris-CAR-T cells",
    "autologous inverse-correlated dual-target truncated IL7Ra-modified CAR-expressing T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-il-7ra-expressing-tris-car-t-cells/"
}