fazarabine

{
  "id": "MLC-T-ONC-003145",
  "term": "fazarabine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "An anticancer drug that is a type of antimetabolite.",
    "An orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug."
  ],
  "abbreviation": "ARA-AC",
  "synonyms": [
    "Kymarabine"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fazarabine/"
}