anti-CD40 agonist monoclonal antibody ABBV-927

{
  "id": "MLC-T-ONC-010387",
  "term": "anti-CD40 agonist monoclonal antibody ABBV-927",
  "field": "Oncology and biomedicine",
  "definition": "An agonistic monoclonal antibody directed against the B-cell surface antigen CD40, with potential antineoplastic activity. Upon administration, ABBV-927 binds to CD40 on a variety of immune cell types. This induces CD40-dependent signaling pathways, triggers the proliferation and activation of antigen-presenting cells (APCs), and activates T cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells and plays a key role in the activation of the immune system.",
  "synonyms": [
    "anti-CD40 monoclonal antibody ABBV-927",
    "agonistic anti-CD40 monoclonal antibody ABBV-927"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd40-agonist-monoclonal-antibody-abbv-927/"
}