anti-CD40/anti-TAA bispecific monoclonal antibody ABBV-428

{
  "id": "MLC-T-ONC-010392",
  "term": "anti-CD40/anti-TAA bispecific monoclonal antibody ABBV-428",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific monoclonal antibody composed of a binding domain for an epitope found on the cell-surface receptor CD40 linked to a binding domain directed to an as of yet undisclosed tumor-associated antigen (TAA), with potential immunomodulating and antineoplastic activities. Upon administration of anti-CD40/anti-TAA bispecific monoclonal antibody ABBV-428, the anti-TAA moiety targets and binds to the TAA expressed on the tumor cells. The agonistic anti-CD40 moiety targets and binds to various CD40-expressing immune cells. This leads to the activation and proliferation of effector and memory T cells, and enhances the immune response against tumor cells, which kills and inhibits the proliferation of the TAA-expressing tumor cells. CD40, a stimulatory receptor and a member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as macrophages, B lymphocytes, and dendritic cells (DCs); it plays a key role in the activation of the immune system.",
  "synonyms": [
    "anti-CD40 x anti-TAA bispecific monoclonal antibody ABBV-428"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd40-anti-taa-bispecific-monoclonal-antibody-abbv-428/"
}