Enadenotucirev-expressing anti-CD40 agonistic monoclonal antibody NG-350

{
  "id": "MLC-T-ONC-013331",
  "term": "Enadenotucirev-expressing anti-CD40 agonistic monoclonal antibody NG-350",
  "field": "Oncology and biomedicine",
  "definition": "An oncolytic adenoviral vector, enadenotucirev (EnAd), that expresses a full-length agonistic anti-CD40 monoclonal antibody, with potential immunomodulating and antineoplastic activities. Upon intratumoral administration of NG-350A, enadenotucirev specifically infects and replicates in tumor cells and not in normal, noncancerous tissue, and selectively expresses the agonistic anti-CD40 antibody. The locally expressed anti-CD40 antibody targets and binds to CD40 on a variety of immune cells, including B cells, T cells and dendritic cells (DCs) in the tumor microenvironment (TME). This induces CD40-dependent signaling pathways, which activates these immune cells and induces a cytotoxic T-lymphocyte (CTL)-mediated antitumor immune response and leads to tumor cell death. CD40, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells and plays a key role in the activation of the immune system.",
  "synonyms": [
    "oncolytic adenoviral vector expressing anti-CD40 antibody NG-350A",
    "oncolytic adenoviral vector-expressing anti-CD40 agonistic antibody NG-350A"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/enadenotucirev-expressing-anti-cd40-agonistic-monoclonal-antibody-ng-350/"
}