anti-CNTN4 antibody GENA-104A16

{
  "id": "MLC-T-ONC-010540",
  "term": "anti-CNTN4 antibody GENA-104A16",
  "field": "Oncology and biomedicine",
  "definition": "An affinity-matured humanized monoclonal antibody directed against the inhibitory immune checkpoint protein contactin 4 (contactin-4; CNTN4), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CNTN4 monoclonal antibody GENA-104A16 targets and binds to CNTN4 expressed on cancer cells. This abrogates CNTN4-mediated immune suppression, decreases regulatory T cells (Tregs), and may restore and increase CD4+ and CD8+ T-cell proliferation and activation and the release of inflammatory cytokines. This may lead to a cytotoxic T-lymphocyte (CTL)-mediated killing of tumor cells that overexpress CNTN4. CNTN4 negatively regulates T-cell activity through binding with amyloid precursor protein (APP) on T cells. It is overexpressed on a variety of tumor cell types.",
  "synonyms": [
    "anti-contactin-4 monoclonal antibody GENA-104A16"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cntn4-antibody-gena-104a16/"
}