anti-epidermal growth factor receptor 2 antibody expressing pluripotent killer T lymphocytes

{
  "id": "MLC-T-ONC-010644",
  "term": "anti-epidermal growth factor receptor 2 antibody expressing pluripotent killer T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A specific population of pluripotent killer (PIK) T cells that have been induced to express high levels of antibodies against human epidermal growth factor receptor 2 (ERBB2; HER2), with potential antitumor activity. Although the exact mechanism(s) of action through which PIK-HER2 cells exert their effects has yet to be elucidated, upon infusion, these cells secrete antibodies targeting HER2 expressed on the surface of tumor cells. This may inhibit HER2-dependent signaling, which may lead to inhibition of cellular proliferation and differentiation. Additionally, these cells may stimulate the host immune system to mount both a highly-specific cytotoxic T-lymphocyte (CTL) response and antibody-dependent cell cytotoxicity (ADCC) directed against HER2-overexpressing tumors, which leads to tumor cell lysis. HER2 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases and is frequently overexpressed in solid tumors.",
  "synonyms": [
    "anti-epidermal growth factor receptor 2 antibody expressing pluripotent killer T cells",
    "PIK-HER2",
    "anti-ERBB2 antibody expressing pluripotent killer T lymphocytes",
    "anti-HER2 antibody expressing pluripotent killer T lymphocytes",
    "anti-ERBB2 antibody expressing pluripotent killer T cells",
    "anti-HER2 antibody expressing pluripotent killer T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-epidermal-growth-factor-receptor-2-antibody-expressing-pluripotent-killer-t/"
}