anti-FGFR3 antibody-drug conjugate LY3076226

{
  "id": "MLC-T-ONC-010656",
  "term": "anti-FGFR3 antibody-drug conjugate LY3076226",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a human monoclonal antibody against the fibroblast growth factor receptor type 3 (FGFR3) that is conjugated to an undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration, the antibody moiety of anti-FGFR3 ADC LY3076226 binds to FGFR3. Upon internalization, the cytotoxic moiety causes cell death in FGFR3-expressing tumor cells. FGFR3, a receptor tyrosine kinase upregulated or mutated in many tumor cell types, plays a key role in tumor cell proliferation.",
  "synonyms": [
    "anti-FGFR3 ADC LY3076226",
    "ADC LY3076226",
    "anti-fibroblast growth factor receptor 3 antibody-drug conjugate LY3076226"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-fgfr3-antibody-drug-conjugate-ly3076226/"
}