anti-FGFR3 monoclonal antibody MFGR1877S

{
  "id": "MLC-T-ONC-010657",
  "term": "anti-FGFR3 monoclonal antibody MFGR1877S",
  "field": "Oncology and biomedicine",
  "definition": "A human monoclonal antibody against the fibroblast growth factor receptor type 3 (FGFR3), with potential antineoplastic activity. Upon administration, the anti-FGFR3 antibody MFGR1877S binds to and inhibits FGFR3, which may result in the inhibition of both FGFR3 phosphorylation and FGFR3-mediated signal transduction pathways. This results in the inhibition of cell proliferation and the induction of cell death in FGFR3-expressing tumor cells. FGFR3, upregulated or mutated in many tumor cell types, is a receptor tyrosine kinase, and plays a key role in tumor cell proliferation.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-fgfr3-monoclonal-antibody-mfgr1877s/"
}