anti-FGFR4 monoclonal antibody U3-1784

{
  "id": "MLC-T-ONC-010658",
  "term": "anti-FGFR4 monoclonal antibody U3-1784",
  "field": "Oncology and biomedicine",
  "definition": "A human monoclonal antibody against human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, U3-1784 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-fgfr4-monoclonal-antibody-u3-1784/"
}