FGFR4 inhibitor H3B-6527

{
  "id": "MLC-T-ONC-013590",
  "term": "FGFR4 inhibitor H3B-6527",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, H3B-6527 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival; FGFR4 expression is associated with poor prognosis.",
  "synonyms": [
    "fibroblast growth factor receptor 4 inhibitor H3B-6527"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fgfr4-inhibitor-h3b-6527/"
}