FGFR3 inhibitor LOXO-435

{
  "id": "MLC-T-ONC-013587",
  "term": "FGFR3 inhibitor LOXO-435",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable, selective inhibitor of human fibroblast growth factor receptor 3 (FGFR3), with potential antineoplastic activity. Upon oral administration, FGFR3 inhibitor LOXO-435 specifically targets and binds to FGFR3, including FGFR3 gatekeeper resistance mutations. This blocks FGFR3-mediated signaling and leads to an inhibition of tumor cell proliferation in FGFR3-overexpressing cells. FGFR3, a receptor tyrosine kinase, is involved in angiogenesis and in the proliferation, differentiation, and survival of tumor cells. FGFR3 expression is associated with poor prognosis. It is overexpressed and/or mutated by certain tumor cell types.",
  "synonyms": [
    "FGFR3 inhibitor LY3866288"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fgfr3-inhibitor-loxo-435/"
}