anti-fucosyl-GM1 monoclonal antibody BMS-986012

{
  "id": "MLC-T-ONC-010675",
  "term": "anti-fucosyl-GM1 monoclonal antibody BMS-986012",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody directed against the ganglioside fucosyl-GM1, with potential antineoplastic and immunomodulating activities. Upon administration, anti-fucosyl-GM1 monoclonal antibody BMS-986012 binds to fucosyl-GM1 on cancer cells and may activate both antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity against the bound tumor cells. This may inhibit the proliferation of GM1-expressing tumor cells. Fucosyl-GM1, a sphingolipid monosialoganglioside and tumor-associated antigen (TAA), is overexpressed on the surface of many cancer cells while its expression is minimal or non-existent in normal tissues.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-fucosyl-gm1-monoclonal-antibody-bms-986012/"
}