anti-GARP monoclonal antibody DS-1055a

{
  "id": "MLC-T-ONC-010679",
  "term": "anti-GARP monoclonal antibody DS-1055a",
  "field": "Oncology and biomedicine",
  "definition": "An afucosylated human monoclonal antibody directed against the transforming growth factor beta (TGFbeta) activator glycoprotein A repetitions predominant (GARP; leucine-rich repeat-containing protein 32; LRRC32), with potential immunomodulating and antineoplastic activities. Upon administration, anti-GARP monoclonal antibody DS-1055a selectively targets and binds to GARP and depletes GARP-positive regulatory T cells (Tregs). This leads to a reversal of immunosuppression mediated by GARP-positive Tregs and enhances the immune response to tumor cells. GARP, a transmembrane protein highly expressed on activated, immunosuppressive Tregs in the tumor microenvironment (TME), is essential for the expression of TGFbeta on the cell surface of activated Tregs; it plays an important role in regulation of the immune cell function and the immunosuppressive nature of Tregs.",
  "synonyms": [
    "anti-glycoprotein A repetitions predominant monoclonal antibody DS-1055a"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-garp-monoclonal-antibody-ds-1055a/"
}