Tagmokitug

{
  "id": "MLC-T-ONC-016965",
  "term": "Tagmokitug",
  "field": "Oncology and biomedicine",
  "definition": "A human immunoglobulin G1 (IgG1) afucosylated monoclonal antibody against C-C-chemokine receptor 8 (CCR8), with potential immunomodulating and antineoplastic activities. Upon administration, tagmokitug targets and binds to CCR8 on CCR8-positive tumor-infiltrating regulatory T cells (Tregs) in the tumor microenvironment (TME), and depletes CCR8-positive tumor-infiltrating Tregs via antibody-dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP). This may reactivate antitumor immune responses. CCR8 is specifically expressed by tumor-infiltrating Tregs in multiple types of cancer and plays a key role in immunosuppression.",
  "synonyms": [
    "anti-CCR8 monoclonal antibody CHS-114",
    "anti-CCR8 monoclonal antibody SRF114"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tagmokitug/"
}