anti-CCR8 monoclonal antibody CM369

{
  "id": "MLC-T-ONC-010206",
  "term": "anti-CCR8 monoclonal antibody CM369",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody against C-C-chemokine receptor 8 (CCR8), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CCR8 monoclonal antibody CM369 targets and binds to CCR8 on CCR8-positive tumor-infiltrating regulatory T cells (Tregs) in the tumor microenvironment (TME), and depletes CCR8-positive tumor-infiltrating Tregs via antibody-dependent cellular cytotoxicity (ADCC). This may reactivate antitumor immune responses. CCR8 is specifically expressed by tumor-infiltrating Tregs in multiple types of cancer and plays a key role in immunosuppression.",
  "synonyms": [
    "anti-CCR8 monoclonal antibody ICP-B05"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ccr8-monoclonal-antibody-cm369/"
}