anti-CCR8 monoclonal antibody RO7502175

{
  "id": "MLC-T-ONC-010209",
  "term": "anti-CCR8 monoclonal antibody RO7502175",
  "field": "Oncology and biomedicine",
  "definition": "A humanized immunoglobulin G1 (IgG1) afucosylated monoclonal antibody directed against C-C-chemokine receptor 8 (CCR8), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CCR8 monoclonal antibody RO7502175 targets and binds to the N-terminus of CCR8 on CCR8-positive, immunosuppressive tumor-infiltrating T regulatory (TITR) cells in the tumor microenvironment (TME). This depletes CCR8-positive TITR cells via antibody-dependent cell-mediated cytotoxicity (ADCC), which may reverse the suppression of CD8+ effector T cells and reactivate antitumor immune responses. CCR8 is specifically expressed by TITR cells in multiple types of cancer and plays a key role in immunosuppression.",
  "synonyms": [
    "anti-C-C motif chemokine receptor 8 monoclonal antibody RO7502175"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ccr8-monoclonal-antibody-ro7502175/"
}