anti-CCR8 monoclonal antibody GS-1811

{
  "id": "MLC-T-ONC-010207",
  "term": "anti-CCR8 monoclonal antibody GS-1811",
  "field": "Oncology and biomedicine",
  "definition": "A humanized immunoglobulin G1 (IgG1) afucosylated monoclonal antibody against C-C-chemokine receptor 8 (CCR8), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CCR8 monoclonal antibody GS-1811 targets and binds to CCR8 on CCR8-positive, immunosuppressive tumor-infiltrating T-regulatory (TITR) cells in the tumor microenvironment (TME), and prevents chemokine ligand 1 (CCL1)-CCR8-mediated signaling. GS-1811 depletes CCR8-positive TITR cells via antibody-dependent cell-mediated cytotoxicity (ADCC), which may reactivate antitumor immune responses. CCR8 is specifically expressed by TITR cells in multiple types of cancer and plays a key role in immunosuppression.",
  "synonyms": [
    "anti-C-C-chemokine receptor 8 monoclonal antibody GS-1811"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-ccr8-monoclonal-antibody-gs-1811/"
}