anti-globo H/MMAE antibody-drug conjugate OBI 999

{
  "id": "MLC-T-ONC-010707",
  "term": "anti-globo H/MMAE antibody-drug conjugate OBI 999",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of OBI-888 (OBI 888), a humanized monoclonal antibody directed against the tumor-associated antigen (TAA) globohexaosylceramide (globo H), covalently linked to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule disrupting agent, with potential antineoplastic activity. Upon administration of anti-globo H/MMAE ADC OBI 999, the antibody moiety of OBI 999, OBI 888, targets and binds to globo H on tumor cells and is rapidly internalized, thereby delivering MMAE intracellularly. Upon proteolytic cleavage, MMAE targets and binds to tubulin and inhibits its polymerization, resulting in G2/M checkpoint arrest and apoptosis in globo H-expressing tumor cells. Globo H, a hexasaccharide glycosphingolipid, is (over)expressed on the surface of many types of tumor cells. Globo H is minimally or not expressed on healthy, normal cells; its expression on cancer cells is associated with increased proliferation and poor prognosis.",
  "synonyms": [
    "ADC OBI 999",
    "OBI-888/MMAE ADC OBI-999",
    "anti-globo H/MMAE ADC OBI 999"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-globo-h-mmae-antibody-drug-conjugate-obi-999/"
}