Globo H-DT vaccine OBI-833

{
  "id": "MLC-T-ONC-013966",
  "term": "Globo H-DT vaccine OBI-833",
  "field": "Oncology and biomedicine",
  "definition": "A carbohydrate-based vaccine comprised of the Globo H hexasaccharide 1 (Globo H) antigen conjugated to DT-CRM197, a non-toxic, mutated form of diphtheria toxin (DT), with potential immunostimulating and antineoplastic activities. Upon administration of Globo H-DT vaccine OBI-833, the carbohydrate antigen Globo H may stimulate a cytotoxic T-lymphocyte (CTL) response against Globo H-expressing tumor cells, thereby decreasing tumor cell proliferation. The hexasaccharide Globo H is a tumor-associated antigen (TAA) commonly found on a variety of tumor cells. DT-CRM197 is used to increase the immunogenicity of the Globo H carbohydrate antigen.",
  "synonyms": [
    "Globo H-CRM197 vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/globo-h-dt-vaccine-obi-833/"
}