anti-GPR20/DXd antibody-drug conjugate DS-6157a

{
  "id": "MLC-T-ONC-010718",
  "term": "anti-GPR20/DXd antibody-drug conjugate DS-6157a",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the G protein-coupled receptor 20 (GPR20) conjugated to the cytotoxic DNA topoisomerase I inhibitor and exatecan derivative DXd (MAAA-1181a; MAAA-1181), with potential antineoplastic activity. Upon administration of the anti-GPR20/DXd ADC DS-6157a, the anti-GPR20 antibody targets and binds to GPR20-expressing tumor cells. Upon cellular uptake, the DXd moiety targets and binds to DNA topoisomerase I, thereby stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication and apoptosis. This inhibits the proliferation of GPR20-expressing tumor cells. GPR20 is overexpressed on certain tumor cell types.",
  "synonyms": [
    "ADC DS-6157a",
    "anti-GPR20 ADC DS-6157a",
    "anti-GPR20/DXd ADC DS-6157a"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-gpr20-dxd-antibody-drug-conjugate-ds-6157a/"
}