anti-GPRC5D monoclonal antibody SAR446523

{
  "id": "MLC-T-ONC-010719",
  "term": "anti-GPRC5D monoclonal antibody SAR446523",
  "field": "Oncology and biomedicine",
  "definition": "A Fc-engineered immunoglobulin G1 (IgG1) monoclonal antibody directed against the tumor-associated antigen (TAA) human G-protein coupled receptor family C group 5 member D (GPRC5D), with potential immunomodulating and antineoplastic activities. Upon administration, anti-GPRC5D monoclonal antibody SAR446523 targets and binds to GPRC5D expressed on certain tumor cells. This results in an antibody-dependent cell-mediated cytotoxicity (ADCC) against GPRC5D-expressing tumor cells, thereby killing the cancer cells. GPRC5D is overexpressed on certain tumors, such as multiple myeloma, while minimally expressed on normal, healthy cells, and plays a key role in tumor cell proliferation.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-gprc5d-monoclonal-antibody-sar446523/"
}