Autologous anti-GPRC5D-CAR-4-1BB-expressing T cells MCARH109

{
  "id": "MLC-T-ONC-011446",
  "term": "Autologous anti-GPRC5D-CAR-4-1BB-expressing T cells MCARH109",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) specific for the tumor-associated antigen (TAA) human G-protein coupled receptor family C group 5 member D (GPRC5D) and the co-stimulatory domain 4-1BB (CD137), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-GPRC5D-CAR-4-1BB-expressing T cells MCARH109 specifically recognize and induce selective toxicity in GPRC5D-expressing tumor cells. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation.",
  "synonyms": [
    "autologous anti-GPRC5D CAR T cells MCARH109",
    "autologous GPRC5D-targeted CAR T cells MCARH109",
    "autologous anti-GPRC5D CAR-T cells MCARH109"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-gprc5d-car-4-1bb-expressing-t-cells-mcarh109/"
}