autologous anti-GPRC5D CAR-T cells OriCAR-017

{
  "id": "MLC-T-ONC-011445",
  "term": "autologous anti-GPRC5D CAR-T cells OriCAR-017",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human G-protein coupled receptor family C group 5 member D (GPRC5D), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-GPRC5D CAR-T cells OriCAR-017 specifically recognize and induce selective toxicity in GPRC5D-expressing tumor cells. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation. OriCAR-017 contains a signal activation domain element that may improve CAR-T cells expansion and durability.",
  "synonyms": [
    "autologous anti-GPRC5D CAR T-cells OriCAR-017",
    "autologous GPRC5D CAR T cells OriCAR-017",
    "autologous GPRC5D-directed CAR T cells OriCAR-017",
    "autologous GPRC5D-targeted CAR T cells OriCAR-017"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-gprc5d-car-t-cells-oricar-017/"
}