anti-GPRC5D/anti-CD3 bispecific antibody LBL-034

{
  "id": "MLC-T-ONC-010721",
  "term": "anti-GPRC5D/anti-CD3 bispecific antibody LBL-034",
  "field": "Oncology and biomedicine",
  "definition": "A humanized immunoglobulin G1 (IgG1) bispecific monoclonal antibody directed against human CD3, a T-cell surface antigen, and human G-protein coupled receptor family C group 5 member D (GPRC5D), a tumor-associated antigen (TAA), with potential immunomodulating and antineoplastic activities. Upon administration, anti-GPRC5D/anti-CD3 bispecific antibody LBL-034 binds to both CD3 on T cells and GPRC5D expressed on tumor cells. This results in the cross-linking of T cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against GPRC5D-expressing tumor cells. GPRC5D is overexpressed on certain tumors while minimally expressed on normal, healthy cells. It plays a key role in tumor cell proliferation.",
  "synonyms": [
    "anti-CD3/anti-GPRC5D bispecific monoclonal antibody LBL-034",
    "anti-GPRC5D/CD3 bispecific antibody LBL-034",
    "GPRC5D x CD3 bispecific antibody LBL-034"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-gprc5d-anti-cd3-bispecific-antibody-lbl-034/"
}