anti-IL-1 alpha monoclonal antibody XB2001

{
  "id": "MLC-T-ONC-010809",
  "term": "anti-IL-1 alpha monoclonal antibody XB2001",
  "field": "Oncology and biomedicine",
  "definition": "A human immunoglobulin G4 (IgG4) monoclonal antibody directed against the inflammatory cytokine interleukin-1 alpha (IL1a), with potential antineoplastic, anti-cachectic and anti-angiogenic activities. Upon administration, anti-IL1a monoclonal antibody XB2001 targets, binds to, and inhibits the activity of IL1a. This may inhibit IL1a-mediated tumorigenesis, angiogenesis and cachexia. IL1a, an inflammatory mediator expressed on monocytes, platelets and overexpressed by certain tumors, plays a key role in the promotion of tumor cell growth, metastasis and invasion. In addition, IL1a mediates metabolic activity, which may cause fatigue, anorexia, and anxiety.",
  "synonyms": [
    "anti-IL1a monoclonal antibody XB2001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-il-1-alpha-monoclonal-antibody-xb2001/"
}