anti-interleukin-1 alpha monoclonal antibody MABp1

{
  "id": "MLC-T-ONC-010830",
  "term": "anti-interleukin-1 alpha monoclonal antibody MABp1",
  "field": "Oncology and biomedicine",
  "definition": "A human IgG1 monoclonal antibody targeting the inflammatory cytokine interleukin-1 alpha (IL1a) with potential antineoplastic, anti-cachectic and anti-angiogenic activities. Anti-IL1a monoclonal antibody MABp1 targets and binds to IL1a and prevents IL1a activity. This prevents IL1a-mediated tumorigenesis and angiogenesis. In addition, MABp1 abrogates IL1a-mediated cachexia. IL1a, an inflammatory mediator expressed on monocytes, platelets and overexpressed by certain tumors, plays a key role in the promotion of tumor cell growth, metastasis and invasion. In addition, IL1a stimulates metabolic activity in the central nervous system.",
  "synonyms": [
    "Anti-IL-1 alpha monoclonal antibody MABp1",
    "Anti-IL-1amonoclonal antibody"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-interleukin-1-alpha-monoclonal-antibody-mabp1/"
}