anti-TNFR2 monoclonal antibody HFB200301

{
  "id": "MLC-T-ONC-011142",
  "term": "anti-TNFR2 monoclonal antibody HFB200301",
  "field": "Oncology and biomedicine",
  "definition": "A humanized agonistic monoclonal antibody directed against tumor necrosis factor receptor 2 (TNFR2; tumor necrosis factor receptor superfamily member 1B; TNFRSF1B), with potential antineoplastic activity. Upon administration, anti-TNFR2 monoclonal antibody HFB200301 targets and binds to TNFR2 expressed on the surface of CD4+ T cells, CD8+ T cells and natural killer (NK) cells in the tumor micro-environment (TME), thereby activating CD4+ T cells, CD8+ T cells and NK cells. This may enhance T-cell- and NK cell- mediated immune responses against tumor cells. TNFR2, a member of the TNFR family of co-stimulatory molecules, plays an important role in T-cell co-stimulation.",
  "synonyms": [
    "anti-TNFR2 agonist antibody HFB200301"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-tnfr2-monoclonal-antibody-hfb200301/"
}