anti-TNFR2 monoclonal antibody BI-1808

{
  "id": "MLC-T-ONC-011140",
  "term": "anti-TNFR2 monoclonal antibody BI-1808",
  "field": "Oncology and biomedicine",
  "definition": "A human immunoglobulin G1 (IgG1) monoclonal antibody directed against tumor necrosis factor Receptor 2 (TNFR2; tumor necrosis factor receptor superfamily member 1B; TNFRSF1B), with potential antineoplastic activity. Upon administration, anti-TNFR2 monoclonal antibody BI-1808 targets and binds to TNFR2 on tumor-associated regulatory T cells (Tregs) in the tumor microenvironment (TME), thereby preventing TNFR2-mediated signaling. This depletes intra-tumoral Tregs, induces and expands intra-tumoral CD8+ T cells, thereby enhancing T-cell-mediated immune responses against tumor cells. TNFR2 plays a role in tumor necrosis factor signaling, tumor expansion and survival.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-tnfr2-monoclonal-antibody-bi-1808/"
}