apolizumab

{
  "id": "MLC-T-ONC-000688",
  "term": "apolizumab",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of hematologic (blood) cancers. Apolizumab binds to a protein called ID10, which is found on the surface of some types of immune cells and cancer cells. It may help the immune system kill cancer cells. It is a type of monoclonal antibody.",
    "A humanized monoclonal antibody directed against 1D10, a polymorphic determinant on the HLA-DR beta chain that is expressed on normal and neoplastic B cells. Apolizumab induces complement-mediated cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and apoptosis of 1D10 antigen-positive B cells in vitro."
  ],
  "abbreviation": "MOAB 1D10",
  "synonyms": [
    "monoclonal antibody 1D10",
    "monoclonal antibody Hu1D10",
    "1D1O anti-lymphoma antibody",
    "1D10 anti-lymphoma antibody",
    "MAbHu1D10"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/apolizumab/"
}