Autologous 4-1BB selected tumor infiltrating lymphocytes

{
  "id": "MLC-T-ONC-011316",
  "term": "Autologous 4-1BB selected tumor infiltrating lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous tumor infiltrating lymphocytes (TILs) expressing the co-stimulatory signaling domain 4-1BB (CD137), with potential antineoplastic activity. TILs are isolated from a patient's tumor and those expressing 4-1BB are selected for expansion in vitro. Upon re-infusion into the patient, the 4-1BB-expressing TILs re-infiltrate the tumor to initiate tumor cell lysis. 4-1BB, a member of the tumor necrosis factor (TNF) receptor superfamily, enhances TIL survival and antitumor cytolytic activity.",
  "synonyms": [
    "autologous 4-1BB selected TILs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-4-1bb-selected-tumor-infiltrating-lymphocytes/"
}