autologous BAFF-expressing CAR T cells LMY-920

{
  "id": "MLC-T-ONC-011506",
  "term": "autologous BAFF-expressing CAR T cells LMY-920",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous cluster of differentiation 4 (CD4) -and CD8 positive T lymphocytes that are genetically engineered, using the non-viral transposon system, to express a chimeric antigen receptor (CAR) expressing the B-cell activating factor (BAFF) ligand and targeting BAFF receptor family members, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous BAFF-expressing CAR T cells LMY-920 are directed to, specifically bind to, and induce selective toxicity in tumor cells expressing any of the three BAFF receptor family members, including BAFF receptor (BAFF-R), B-cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI). Almost all B-cell cancers are reported to express at least one of these three receptors which play a key role in the regulation of peripheral B-cell survival.",
  "synonyms": [
    "BAFF CAR T cells LMY-920",
    "ligand-based BAFF CAR T cells LMY-920",
    "BAFF ligand-based CAR T cells LMY-920"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-baff-expressing-car-t-cells-lmy-920/"
}