autologous IL-2-expressing B-CLL vaccine

{
  "id": "MLC-T-ONC-011665",
  "term": "autologous IL-2-expressing B-CLL vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of autologous, B-chronic lymphocytic leukemia (B-CLL) cells harvested from a patient and transduced ex vivo with an adenoviral vector encoding the gene for the human cytokine interleukin-2 (IL-2), with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient, the autologous IL-2-expressing B-CLL vaccine expresses IL-2, stimulates natural killer (NK) cells, and may enhance the cytotoxic T-lymphocyte (CTL) immune response against the patient's B-CLL cells.",
  "synonyms": [
    "autologous IL2-transduced CLL B cell vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-il-2-expressing-b-cll-vaccine/"
}