autologous natural killer cell-like CTLs

{
  "id": "MLC-T-ONC-011712",
  "term": "autologous natural killer cell-like CTLs",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of cytotoxic T lymphocytes (CTLs) that express natural killer (NK)-like features (nCTLs), with potential immunomodulating and antineoplastic activities. The nCTLs are derived from autologous lymphocytes that have been in vitro exposed to autologous alpha-type-1 polarized dendritic cells that are pulsed with specific autologous tumor-associated antigens (TAAs); the nCTLs are subsequently expanded in the presence of the cytokine human interleukin-2 (IL-2). The generated nCTLs are potent CTLs that produce high amounts of granzyme B and perforin, and interferon-gamma (IFNg) with high killer activity and tumor-homing potential. Upon infusion of the autologous nCTLs, these cells specifically recognize the TAAs on the tumor cells, then bind to and directly lyse tumor cells.",
  "synonyms": [
    "therapeutic iNKT cells",
    "autologous nCTLs",
    "autologous natural killer-like cytotoxic lymphocytes",
    "autologous NK-like CTLs",
    "in-vitro DC-sensitized autologous CTLs",
    "autologous aDC1-induced CTLs",
    "autologous CTLs sensitized ex-vivo with autologous TAA-loaded alphaDC1",
    "tumor neo-antigen-specific nCTLs",
    "in vitro DC-sensitized CTLs",
    "therapeutic nCTLs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-natural-killer-cell-like-ctls/"
}