Autologous native ESR1-pulsed DC1 vaccine alternating with autologous mutated ESR1-pulsed DC1 vaccine

{
  "id": "MLC-T-ONC-011711",
  "term": "Autologous native ESR1-pulsed DC1 vaccine alternating with autologous mutated ESR1-pulsed DC1 vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A dendritic cell (DC)-based cancer vaccine composed of autologous, type-1 polarized dendritic cells (DC1s) pulsed with either native or mutated estrogen receptor alpha (ERa; estrogen receptor 1; ESR1), with potential immunomodulatory and antineoplastic activities. Autologous DCs were treated to produce DC1s and pulsed with either native or mutated ESR1. Alternating weekly between autologous native ESR1-pulsed and mutated ESR1-pulsed DC1 vaccine, upon administration, the autologous native and/or mutated ESR1-pulsed DC1 vaccine may stimulate a potent cytotoxic T-lymphocyte (CTL) response against ESR1-positive tumor cells, which may result in tumor cell death and decreased tumor growth. ESR1 is overexpressed and/or mutated in certain cancers.",
  "synonyms": [
    "autologous DC1s pulsed with native or mutated ESR1",
    "autologous native ESR1-pulsed DC1s/mutated ESR1-pulsed DC1s"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-native-esr1-pulsed-dc1-vaccine-alternating-with-autologous-mutated/"
}