autologous MuSK-CD3z/4-1BB-expressing chimeric autoantibody receptor T cells MuSK-CAART

{
  "id": "MLC-T-ONC-011710",
  "term": "autologous MuSK-CD3z/4-1BB-expressing chimeric autoantibody receptor T cells MuSK-CAART",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been engineered to express a chimeric autoantibody receptor (CAAR) containing the autoantigen muscle, skeletal receptor tyrosine-protein kinase (MuSK; muscle-specific kinase) that is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunomodulatory activity. Upon administration, the autologous MuSK-CD3z/4-1BB-expressing CAAR T cells MuSK-CAART specifically recognize and induce selective toxicity in aberrant B cells expressing MuSK autoantibodies. This inhibits the production of MuSK autoantibodies. MuSK is a transmembrane protein expressed on skeletal muscle cell membrane that plays an important role in the formation and maintenance of the neuromuscular junction. MuSK autoantibodies are produced and expressed by aberrant B cells in MuSK-associated myasthenia gravis.",
  "abbreviation": "MuSK-CAART",
  "synonyms": [
    "autologous MuSK-CD3z/4-1BB-expressing CAAR T cells MuSK-CAART",
    "autologous MuSK CAAR T cells MuSK-CAART",
    "autologous MuSK-CD3z/4-1BB-expressing CAART MuSK-CAART",
    "autologous MuSK CAAR-expressing T cells MuSK-CAART",
    "autologous anti-MuSK-CD3z/4-1BB-expressing CAART MuSK-CAART"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-musk-cd3z-4-1bb-expressing-chimeric-autoantibody-receptor-t-cells/"
}