autologous desmoglein-3 chimeric autoantibody receptor T cells DSG3-CAART

{
  "id": "MLC-T-ONC-011608",
  "term": "autologous desmoglein-3 chimeric autoantibody receptor T cells DSG3-CAART",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been engineered to express a chimeric autoantibody receptor (CAAR) containing the autoantigen desmoglein-3 (desmoglein 3; DSG3) that is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunomodulatory activity. Upon administration, the autologous DSG3 chimeric autoantibody receptor T cells (CAART) DSG3-CAART specifically recognize and induce selective toxicity in aberrant B cells expressing DSG3 autoantibodies. This inhibits the production of DSG3 autoantibodies. DSG3 is a protein expressed in desmosomes that plays an important role in cell adhesion. DSG3 autoantibodies are produced and expressed by aberrant B cells in the autoimmune disease mucosal-dominant pemphigus vulgaris.",
  "synonyms": [
    "autologous desmoglein 3 chimeric autoantibody receptor T cells DSG3-CAART",
    "autologous desmoglein-3 CAAR-expressing T cells DSG3-CAART",
    "autologous DSG3 CAART DSG3-CAART",
    "autologous DSG3 chimeric autoantibody receptor T cells DSG3-CAART",
    "DSG3 CAART"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-desmoglein-3-chimeric-autoantibody-receptor-t-cells-dsg3-caart/"
}