Autologous CD5KO anti-CD5 CAR 4-1BB-expressing T lymphocytes and autologous CD5KO T lymphocytes

{
  "id": "MLC-T-ONC-011563",
  "term": "Autologous CD5KO anti-CD5 CAR 4-1BB-expressing T lymphocytes and autologous CD5KO T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A dual-population preparation of autologous T lymphocytes in which the tumor-associated antigen (TAA) CD5 is knocked out (CD5KO) and is genetically modified to express a chimeric antigen receptor (CAR) specific for CD5 and coupled to the co-stimulatory molecule 4-1BB (CD137), and autologous CD5KO normal untransduced T lymphocytes, with potential immunomodulating and antineoplastic activities. Upon administration of autologous CD5KO anti-CD5 CAR 4-1BB-expressing T lymphocytes and autologous CD5KO T lymphocytes, the autologous CD5KO anti-CD5 CAR 4-1BB-expressing T lymphocytes specifically recognize and kill CD5-expressing tumor cells. CD5 is a T-cell surface glycoprotein expressed on the surface of normal T cells and overexpressed on various B- and T-cell malignancies. CD5 KO in the CART5 cells prevents CART fratricide and enhances CAR-T cell function. The CD5KO normal T cells allow for T-cell reconstitution and may mitigate T-cell toxicity.",
  "synonyms": [
    "autologous CD5-deleted anti-CD5 CAR-T cells and CD5-deleted T cells",
    "autologous CD5KO CART5 cells and CD5KO normal untransduced T cells",
    "autologous Senza5 (R) CART5 cells",
    "CD5 knockout cells and CD5KO-CART5 cells",
    "autologous CD5KO anti-CD5 CAR 4-1BB-expressing T lymphocytes plus autologous CD5KO T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cd5ko-anti-cd5-car-4-1bb-expressing-t-lymphocytes-and-autologous-t/"
}