autologous CD5-specific CAR-28 zeta CAR T cells

{
  "id": "MLC-T-ONC-011564",
  "term": "autologous CD5-specific CAR-28 zeta CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "Autologous T lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD5 single chain variable fragment (scFv) coupled to the costimulatory signaling domain CD28 and the zeta chain of the T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon transfusion, the autologous CD5-specific CAR-28 zeta CAR T cells are directed to and induce selective toxicity in CD5-expressing tumor cells. The tumor-associated antigen (TAA) CD5 is a T-cell surface glycoprotein expressed on the surface of normal T cells, and is overexpressed on various B- and T-cell malignancies; its expression is associated with poor prognosis.",
  "synonyms": [
    "autologous CD5.CAR/28zeta CAR T cells",
    "autologous CD5-specific CAR-28 zeta CAR T lymphocytes",
    "CD5.CAR/28zeta CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cd5-specific-car-28-zeta-car-t-cells/"
}