Allogeneic anti-CD5 CAR T cells

{
  "id": "MLC-T-ONC-009820",
  "term": "Allogeneic anti-CD5 CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for CD5, with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-CD5 CAR T cells target and bind to CD5-expressing tumor cells, thereby inducing selective cytotoxicity in CD5-expressing tumor cells. CD5 is a T-cell surface glycoprotein expressed on the surface of normal T cells and overexpressed on various B- and T-cell malignancies.",
  "synonyms": [
    "donor-derived anti-CD5 CAR T cells",
    "donor-derived CD5 CAR T cells",
    "allogeneic CD5-targeting CAR T cells",
    "allogeneic anti-CD5 CAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd5-car-t-cells/"
}