autologous anti-CD5 CAR monocytes MT-101

{
  "id": "MLC-T-ONC-011402",
  "term": "autologous anti-CD5 CAR monocytes MT-101",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous monocytes genetically modified with mRNA technology to express a chimeric antigen receptor (CAR) specific for CD5, with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CD5 CAR monocytes MT-101 specifically recognize and bind to CD5-expressing tumor cells, and expose the immune system to the CD5 glycoprotein. This may elicit a cytotoxic T-lymphocyte (CTL) response against CD5-expressing tumor cells. CD5 is a T-cell surface glycoprotein expressed on the surface of normal T cells and overexpressed on various B- and T-cell malignancies.",
  "synonyms": [
    "autologous anti-CD5 CAR-M MT-101",
    "CD5 ATAK CAR monocytes MT-101",
    "mRNA-engineered CD5-CAR monocyte MT-101",
    "mRNA-engineered CD5-CAR-M MT-101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd5-car-monocytes-mt-101/"
}