autologous anti-CD4 CAR T cells LB1901

{
  "id": "MLC-T-ONC-011401",
  "term": "autologous anti-CD4 CAR T cells LB1901",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified and transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD4, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD4 CAR T cells LB1901 target and bind to CD4-expressing tumor cells, thereby inducing selective toxicity in CD4-expressing tumor cells. CD4 antigen is expressed in CD4-positive T-cell lymphomas.",
  "synonyms": [
    "autologous CAR T cells LB1901",
    "autologous CD4-specific CAR T cells LB1901",
    "autologous CD4-targeted chimeric antigen receptor T cells LB1901"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd4-car-t-cells-lb1901/"
}