lymphodepleted autologous CD4-directed CAR T cells

{
  "id": "MLC-T-ONC-014945",
  "term": "lymphodepleted autologous CD4-directed CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous peripheral blood T lymphocytes (PBTLs) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the T-cell surface antigen CD4, administered with lymphodepletion, with potential immunostimulating and antineoplastic activities. Upon administration, lymphodepleted autologous CD4-directed CAR T cells specifically recognize and kill CD4-expressing tumor cells. CD4, a tumor-associated antigen (TAA), is overexpressed in various lymphomas, including peripheral T-cell lymphoma, angioimmunoblastic T-cell lymphoma and anaplastic large cell lymphoma.",
  "synonyms": [
    "autologous LCAR-T2C CAR-T cells",
    "autologous LCAR-T2C CAR-T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lymphodepleted-autologous-cd4-directed-car-t-cells/"
}