zanolimumab

{
  "id": "MLC-T-ONC-017652",
  "term": "zanolimumab",
  "field": "Oncology and biomedicine",
  "definition": "A human IgG1k monoclonal antibody against the CD4 receptor on T lymphocytes, with potential antineoplastic and immunosuppressing activities. Zanolimumab targets and binds to the CD4 receptor on certain T cells thereby preventing the interaction between the CD4 receptor and the major histocompatibility complex class II molecule. This prevents activation of CD4-positive T cells. In addition, zanolimumab is able to induce an antibody-dependent cellular cytotoxicity (ADCC) response against CD4-expressing tumor cells. CD4, a receptor located on a subset of T-lymphocytes, is upregulated in T-cell lymphomas.",
  "synonyms": [
    "monoclonal antibody HuMax-CD4",
    "MOAB HuMax-CD4",
    "HuMax-CD4 monoclonal antibody",
    "anti-CD4 monoclonal antibody HuMax"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/zanolimumab/"
}