autologous anti-CD5 CAR T lymphocytes MB-105

{
  "id": "MLC-T-ONC-011403",
  "term": "autologous anti-CD5 CAR T lymphocytes MB-105",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of genetically modified autologous T cells expressing a chimeric antigen receptor (CAR) directed against cluster of differentiation 5 (CD5), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CD5 CAR T lymphocytes MB-105 target and bind to CD5-expressing tumor cells, thereby inducing selective cytotoxicity in CD5-expressing tumor cells. CD5 is a T-cell surface glycoprotein expressed on the surface of normal T cells and overexpressed on various B- and T-cell malignancies.",
  "synonyms": [
    "autologous anti-CD5 CAR T cells MB-105",
    "autologous anti-CD5 CAR-T cells MB-105",
    "autologous CD5-specific CAR T cells MB-105",
    "autologous CD5-targeted CAR-T cells MB-105",
    "autologous CD5CAR-expressing T lymphocytes MB-105"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd5-car-t-lymphocytes-mb-105/"
}