alpha-type-1 polarized dendritic cells

{
  "id": "MLC-T-ONC-009993",
  "term": "alpha-type-1 polarized dendritic cells",
  "field": "Oncology and biomedicine",
  "definition": "A mature polarized dendritic cell with potent immunostimulating activity. Treating dendritic cells (DCs) with interferon-alpha (IFN-a) and polyinosinic:polycytidylic acid (p-I:C) in addition to a cytokine cocktail (tumor necrosis factor alpha/Interleukin-1beta/IFN-gamma) produces mature but not exhausted alpha type-1 polarized DCs (alphaDC1) that are capable of: 1) high responsiveness to other lymphoid chemokines, and 2) producing high level of interleukin-12p70 (IL-12p70). Therefore, alphaDC1 has a much more significant capability of inducing helper T-cell (CD4+ T-cell) responses in comparison with the \"gold standard\" DCs. When pulsed with specific tumor associated antigens (TAAs), alphaDC1 is able to induce a potent cytotoxic T-lymphocyte (CTL) response against TAAs; as a result it can be used as a cancer vaccine.",
  "abbreviation": "alphaDC1",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/alpha-type-1-polarized-dendritic-cells/"
}