B43-PAP immunotoxin

{
  "id": "MLC-T-ONC-000892",
  "term": "B43-PAP immunotoxin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A toxic substance linked to an antibody that attaches to tumor cells and kills them.",
    "A mouse-derived anti-human CD19 monoclonal antibody linked to pokeweed (Phytolacca americana) antiviral protein (PAP) with antileukemic activity. The monoclonal antibody portion specifically binds to the CD19 antigen, a cell surface molecule normally expressed only by B lymphocytes and follicular dendritic cells and over-expressed in B-lineage lymphocytic leukemia cells. Following internalization, PAP, a plant hemitoxin and a ribosome-inactivating protein, is cleaved from the immunoconjugate and released into the cytoplasm where it enzymatically removes a single adenine base from a conserved, surface exposed loop sequence of rRNA leading to inhibition of protein synthesis and cell growth, but not necessarily cell death."
  ],
  "abbreviation": "B43-PAP",
  "synonyms": [
    "B43-pokeweed antiviral protein immunotoxin",
    "B43 immunotoxin"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/b43-pap-immunotoxin/"
}