Bcl-2/Bcl-XL inhibitor LP-118

{
  "id": "MLC-T-ONC-011907",
  "term": "Bcl-2/Bcl-XL inhibitor LP-118",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the anti-apoptotic proteins B-cell lymphoma-2 (Bcl-2) and Bcl-extra large (Bcl-XL), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, Bcl-2/Bcl-XL inhibitor LP-118 selectively targets, binds to and inhibits the activity of Bcl-2 and Bcl-XL. This restores apoptotic processes in tumor cells. Bcl-2 and Bcl-XL, Bcl-2 family proteins overexpressed in many cancers, play important roles in the negative regulation of apoptosis. Their expression is associated with increased drug resistance and tumor cell survival.",
  "synonyms": [
    "Bcl-2/XL inhibitor LP-118"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bcl-2-bcl-xl-inhibitor-lp-118/"
}