BCL2 inhibitor VOB560

{
  "id": "MLC-T-ONC-011906",
  "term": "BCL2 inhibitor VOB560",
  "field": "Oncology and biomedicine",
  "definition": "An inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon intravenous administration, Bcl-2 inhibitor VOB560 binds to and inhibits the activity of Bcl-2, thereby restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in many cancer types and plays an important role in the negative regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival.",
  "synonyms": [
    "Bcl-2 inhibitor S65487"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bcl2-inhibitor-vob560/"
}