c-Myb mRNA degrader RGT-61159

{
  "id": "MLC-T-ONC-012684",
  "term": "c-Myb mRNA degrader RGT-61159",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable, small molecule mRNA modulator of the proto-oncogene c-Myb, with potential antineoplastic activity. Upon oral administration, c-Myb mRNA degrader RGT-61159 targets c-Myb RNA and selectively induces the inclusion of the cryptic \"poison\" exon into the c-Myb RNA transcript, resulting in the elimination of c-Myb mRNA transcript. This inhibits the production of the c-Myb protein. Suppression of c-Myb expression results in the restoration of normal differentiation pathways, increased antiproliferative effects, and the induction of apoptosis in tumor cells that overexpress c-Myb. c-Myb, an oncogenic transcription factor that plays a key role in the regulation of hematopoietic cell differentiation and proliferation, is dysregulated or overexpressed in a variety of tumor cell types.",
  "synonyms": [
    "c-Myb RNA modulator RGT-61159"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/c-myb-mrna-degrader-rgt-61159/"
}